Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10494730 | 0.82 | EPHX1 (0.53) | EPHX1ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL2988155 | 0.81 | MAPT (0.53) | EPHX1ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL2994663 | 0.77 | GAA (0.47) | EPHX1ALDH1A1MAPTMEN1CYP1A2 | |
| SCHEMBL6424076 | 0.73 | IDO1 (0.53) | EPHX1ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL21596169 | 0.72 | LOXL2 (0.55) | MAPTMEN1TSHRKMT2AGAA | |
| SCHEMBL24168053 | 0.70 | EPHX1 (0.51) | EPHX1ALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL3001018 | 0.70 | CA1 (0.58) | ALDH1A1MAPTMEN1TSHRKMT2A | |
| SCHEMBL3099025 | 0.70 | POLB (0.69) | EPHX1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9097319 | 0.70 | CYP19A1 (0.47) | EPHX1ALDH1A1CYP19A1MAPTSMN1; SMN2 | |
| SCHEMBL18177867 | 0.70 | POLB (0.69) | EPHX1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132441-B2 | Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor | G.D. SEARLE & CO. (US) | 2006-11-07 | — | — | US | claimed |
| US-5939069-A | INHIBITING THE DEVELOPMENT OF INSULIN DEPENDENT DIABETES BY ADMINISTERING INDOMETHACIN OR N-2-CYCLOHEXLYOXYNITROPHENYL METHANESULFONAMIDE | UNIVERSITY OF FLORIDA (US) | 1999-08-17 | — | — | US | disclosed |