Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280299 | 0.86 | PTGS1 (0.41) | NR1H3PTPN1PTGS1 | |
| SCHEMBL267558 | 0.85 | KARS1 (0.38) | NR1H3PTPN1PTGS1KARS1MEN1 | |
| SCHEMBL6009546 | 0.85 | KARS1 (0.38) | NR1H3PTPN1PTGS1KARS1MEN1 | |
| SCHEMBL266862 | 0.84 | NR1H3 (0.37) | NR1H3PTPN1PTGS1 | |
| SCHEMBL280434 | 0.83 | CYP19A1 (0.39) | NR1H3PTPN1PTGS1CYP19A1 | |
| SCHEMBL267569 | 0.82 | NR1H3 (0.37) | NR1H3PTPN1PTGS1 | |
| SCHEMBL12450205 | 0.82 | NR1H3 (0.37) | NR1H3PTPN1PTGS1 | |
| SCHEMBL14286750 | 0.81 | NR1H3 (0.58) | NR1H3PTPN1PTGS1KARS1CYP3A4 | |
| SCHEMBL267926 | 0.81 | NR1H3 (0.58) | NR1H3PTPN1PTGS1KARS1CYP3A4 | |
| SCHEMBL12450206 | 0.81 | NR1H3 (0.58) | NR1H3PTPN1PTGS1KARS1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912932-B1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS INC (US) | 2012-05-02 | — | — | EP | disclosed |