Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | POLA1 | P09884 | 4/20 | 0.46 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12704655 | 1.00 | NR1H3 (0.52) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL14610506 | 0.85 | NR1H3 (0.51) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL280071 | 0.85 | NR1H3 (0.54) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL12887757 | 0.85 | NR1H3 (0.54) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL12704708 | 0.84 | NR1H3 (0.58) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL267305 | 0.84 | NR1H3 (0.58) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL266932 | 0.84 | NR1H3 (0.58) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL6008298 | 0.84 | NR1H3 (0.58) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL12704621 | 0.84 | NR1H3 (0.58) | NR1H3PTPN1PTGS1POLA1KARS1 | |
| SCHEMBL14610508 | 0.84 | NR1H3 (0.58) | NR1H3PTPN1PTGS1POLA1KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912932-B1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS INC (US) | 2012-05-02 | — | — | EP | disclosed |