Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30349744 | 0.94 | USP30 (0.52) | USP30PARP1BRD4BACE1HDAC4 | |
| SCHEMBL29123195 | 0.93 | CA1 (0.52) | USP30PARP1CA1CA2BRD4 | |
| SCHEMBL29860886 | 0.93 | CA1 (0.52) | USP30PARP1CA1CA2BRD4 | |
| SCHEMBL2952653 | 0.93 | CA1 (0.52) | USP30PARP1CA1CA2BRD4 | |
| SCHEMBL25355246 | 0.90 | BACE1 (0.46) | USP30BRD4BACE1 | |
| SCHEMBL17997424 | 0.88 | BACE1 (0.49) | USP30PARP1CA1CA2BACE1 | |
| SCHEMBL30171776 | 0.88 | BACE1 (0.49) | USP30PARP1CA1CA2BACE1 | |
| SCHEMBL29625116 | 0.88 | BACE1 (0.49) | USP30PARP1CA1CA2BACE1 | |
| SCHEMBL3489490 | 0.87 | HSD11B1 (0.50) | USP30PARP1CA1CA2BRD4 | |
| SCHEMBL29959044 | 0.87 | BACE1 (0.44) | USP30BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713781-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005075439-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |