⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13937767 | 0.82 | PSMB5 (0.39) | — | |
| SCHEMBL3968280 | 0.81 | — | — | |
| SCHEMBL5909175 | 0.79 | MEN1 (0.52) | — | |
| SCHEMBL16330083 | 0.79 | — | — | |
| SCHEMBL13445357 | 0.77 | MME (0.47) | — | |
| SCHEMBL6010086 | 0.77 | — | — | |
| SCHEMBL3313335 | 0.77 | MEN1 (0.50) | — | |
| SCHEMBL5909062 | 0.77 | MEN1 (0.62) | — | |
| SCHEMBL40805 | 0.77 | MEN1 (0.50) | — | |
| SCHEMBL21123628 | 0.75 | MEN1 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | IMMUNOGEN, INC. (US) | 2023-10-24 | — | — | US | disclosed |
| US-20230063768-A1 | IMMUNOPHILIN BINDING AGENTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-03-02 | — | — | US | disclosed |
| US-20230011665-A1 | SELECTIVE HDAC6 DEGRADERS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-01-12 | — | — | US | disclosed |
| EP-3327027-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2021-07-07 | — | — | EP | disclosed |
| US-11008330-B2 | Tetraphenylporphyrin derivative | KYOTO UNIVERSITY (JP) | 2021-05-18 | — | — | US | disclosed |
| EP-3327027-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2021-01-06 | — | — | EP | disclosed |
| US-20200397914-A1 | BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2020-12-24 | — | — | US | disclosed |
| WO-2020163594-A1 | IMMUNOPHILIN BINDING AGENTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-08-13 | — | — | WO | disclosed |
| US-20200087315-A1 | TETRAPHENYLPORPHYRIN DERIVATIVE | KYOTO UNIVERSITY (JP) | 2020-03-19 | — | — | US | disclosed |
| US-10398783-B2 | Antiproliferative compounds and conjugates made therefrom | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-03 | — | — | US | disclosed |
| US-20130289085-A1 | HISTONE DEACETYLASE (HDAC) INHIBITORS TARGETING PROSTATE TUMORS AND METHODS OF MAKING AND USING THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-31 | — | — | US | disclosed |
| US-8440716-B2 | Deacetylase inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-05-14 | — | — | US | disclosed |
| CN-103003295-A | Intermediate for synthesizing caspofungin and preparation method therefor | UNITRIS BIOPHARMA CO LTD | 2013-03-27 | — | — | CN | disclosed |
| US-20130018103-A1 | BIFUNCTIONAL HISTONE DEACETYLASE INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-01-17 | — | — | US | disclosed |
| US-8304451-B2 | Histone deacetylase and tubulin deacetylase inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-11-06 | — | — | US | disclosed |
| US-20110172303-A1 | DEACETYLASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | GEORGETOWN UNIVERSITY (US) | 2010-08-05 | — | — | US | disclosed |
| US-20090209590-A1 | Histone Deacetylase and Tubulin Deacetylase Inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-08-20 | — | — | US | disclosed |
| EP-0895470-B1 | AGENT AND METHOD FOR PERMANENTLY SHAPING THE HAIR, BASED ON N-BRANCHED-CHAIN ALKYL-SUBSTITUTED MERCAPTO ACETAMIDES | WELLA AG (DE) | 2006-09-20 | — | — | EP | disclosed |
| US-3988328-A | PLANT GROWTH REGULATORS, HERBICIDES | SANDOZ LTD. (CH) | 1976-10-26 | — | — | US | disclosed |