Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 9/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.44 |
| ▸ | CNR2 | P34972 | 4/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3386364 | 0.90 | PDE5A (0.48) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3023423 | 0.86 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CCA12 | |
| SCHEMBL3386997 | 0.86 | PDE5A (0.49) | ALDH1A1SMN1; SMN2PDE5ATSHRBRD4 | |
| SCHEMBL3384950 | 0.83 | PDE5A (0.41) | ALDH1A1PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3031282 | 0.79 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3012495 | 0.78 | PDE5A (0.74) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3023508 | 0.77 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CCA12 | |
| Tunodafil SCHEMBL3018511 | 0.77 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3029660 | 0.76 | PDE5A (0.64) | ALDH1A1PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3383025 | 0.76 | PDE5A (0.36) | PDE5APDE1APDE1BPDE1CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060173025-A1 | 2-Substituted phenyl-5,7-dialkyl-3,7-dihydropyrrole [2,3-d]pyrimidine-4-one derivatives, the preparation and the pharmaceutical use thereof | YANGTZE RIVER PHARMACEUTICAL (GROUP) CO., LTD. (CN) | 2006-08-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173025-A1 | 2-Substituted phenyl-5,7-dialkyl-3,7-dihydropyrrole [2,3-d]pyrimidine-4-one derivatives, the preparation and the pharmaceutical use thereof | PDE5A, PDE3B, PDE2A | ALDH1A1 1203/4885SMN1; SMN2 3347/4885HTT 4762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.