Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27697688 | 0.84 | EPHX1 (0.47) | EPHX1CYP2D6HRH3PIM1PIM2 | |
| SCHEMBL6009169 | 0.80 | MAOB (0.55) | CYP2D6MAOBHDAC1HDAC8KDM1A | |
| SCHEMBL9562264 | 0.80 | MAOB (0.55) | CYP2D6MAOBHDAC1HDAC8KDM1A | |
| SCHEMBL9562365 | 0.80 | MAOB (0.55) | HRH3HTR2CMAOBHDAC1HDAC8 | |
| SCHEMBL9562361 | 0.80 | MAOB (0.55) | HRH3HTR2CMAOBHDAC1HDAC8 | |
| SCHEMBL6011007 | 0.78 | HTR1A (0.46) | KDM1A | |
| Hydrochloric Acid SCHEMBL19994632 | 0.78 | HTR2C (0.54) | HRH3HTR2CMAOBHDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL19994635 | 0.78 | HTR2C (0.54) | HRH3HTR2CMAOBHDAC1HDAC8 | |
| SCHEMBL5213208 | 0.77 | MAOB (0.51) | MAOB | |
| SCHEMBL9060986 | 0.74 | HRH3 (0.38) | CYP2D6HRH3PIM1PIM2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1785415-B1 | PIPERIDINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-05-02 | — | — | EP | disclosed |
| EP-1785415-A1 | PIPERIDINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Astellas Pharma Inc. (JP) | 2007-05-16 | — | — | EP | disclosed |