Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL420358 | 0.72 | IDO1 (0.40) | PDPK1KITKDRFLT3 | |
| SCHEMBL423508 | 0.68 | KDR (0.36) | PDPK1KITKDRFLT3 | |
| SCHEMBL423308 | 0.62 | PDPK1 (0.41) | PDPK1FLT3 | |
| SCHEMBL420454 | 0.59 | HRH4 (0.41) | PDPK1 | |
| SCHEMBL419470 | 0.58 | KDM4E (0.36) | PDPK1 | |
| SCHEMBL27657545 | 0.56 | KDM4E (0.35) | PDPK1KITKDRFLT3 | |
| SCHEMBL2204176 | 0.52 | CA1 (0.32) | — | |
| SCHEMBL423320 | 0.51 | AURKB (0.43) | PDPK1KDRFLT3 | |
| SCHEMBL25668917 | 0.51 | PDPK1 (0.58) | PDPK1KITKDRFLT3 | |
| SCHEMBL16680735 | 0.50 | CLK4 (0.63) | PDPK1KITKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | disclosed |