Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6013125 | 0.83 | GRM6 (0.46) | SMN1; SMN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL14616739 | 0.79 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL5108388 | 0.76 | GCGR (0.50) | SMN1; SMN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL6012756 | 0.76 | GCGR (0.43) | SMN1; SMN2ALDH1A1LMNAKDM4ERAB9A | |
| SCHEMBL6013263 | 0.74 | GCGR (0.48) | SMN1; SMN2ALDH1A1LMNAKDM4ERAB9A | |
| SCHEMBL11494053 | 0.73 | KDM4E (0.73) | SMN1; SMN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL6012892 | 0.73 | GCGR (0.41) | SMN1; SMN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL6012859 | 0.73 | GCGR (0.50) | SMN1; SMN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL5166558 | 0.71 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL8254104 | 0.71 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1LMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684754-A1 | HMG-COA REDUCTASE INHIBITORS AND METHOD | Bristol-Myers Squibb Company (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051386-A1 | HMG-COA REDUCTASE INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |