Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 18/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6012990 | 1.00 | CCR5 (0.45) | CCR5CYP3A4MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5611984 | 0.99 | CCR5 (0.46) | CCR5CYP3A4 | |
| Hydrochloric Acid SCHEMBL5611989 | 0.99 | CCR5 (0.46) | CCR5CYP3A4 | |
| SCHEMBL14404610 | 0.90 | CCR5 (0.49) | CCR5CYP3A4 | |
| SCHEMBL6012607 | 0.90 | CCR5 (0.49) | CCR5 | |
| SCHEMBL6012594 | 0.90 | CCR5 (0.49) | CCR5 | |
| SCHEMBL5343697 | 0.87 | CCR5 (0.60) | CCR5CYP3A4 | |
| SCHEMBL6012695 | 0.87 | CCR5 (0.60) | CCR5CYP3A4 | |
| SCHEMBL6012641 | 0.87 | CCR5 (0.58) | CCR5CYP3A4 | |
| Hydrochloric Acid SCHEMBL6010876 | 0.86 | CCR5 (0.61) | CCR5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119091-B2 | Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-10-10 | — | — | US | claimed |
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | claimed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | claimed |
| EP-1438962-A1 | DRUGS COMPRISING COMBINATION OF TRIAZASPIRO 5,5 U NDECANE DERIVATIVE WITH CYTOCHROME P450 ISOZYME 3A4 INHIBITOR AND/OR P−GLYCOPROTEIN INHIBITOR | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-07-21 | — | — | EP | disclosed |