Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monomethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethyl Maleate SCHEMBL28037663 | 1.00 | HCAR2 (1.00) | — | |
| Dimethyl Maleate SCHEMBL19690393 | 1.00 | HCAR2 (1.00) | — | |
| Monomethyl Fumarate SCHEMBL28468249 | 1.00 | HCAR2 (1.00) | — | |
| Dimethyl Fumarate SCHEMBL15573962 | 1.00 | HCAR2 (1.00) | — | |
| Monomethyl Fumarate SCHEMBL126468 | 1.00 | — | — | |
| Monomethyl Fumarate SCHEMBL25280962 | 1.00 | HCAR2 (1.00) | — | |
| Dimethyl Fumarate SCHEMBL15573963 | 1.00 | HCAR2 (1.00) | — | |
| Monomethyl Fumarate SCHEMBL60133 | 1.00 | — | — | |
| Dimethyl Maleate SCHEMBL6896824 | 1.00 | HCAR2 (1.00) | — | |
| Dimethyl Fumarate SCHEMBL28295894 | 1.00 | HCAR2 (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13336 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4067466-B1 | WASHING OR CLEANING AGENT | HENKEL AG & CO KGAA (DE) | 2026-05-20 | — | — | EP | claimed |
| CN-112803020-B | Adhesive with multi-section crosslinking structure and preparation method and application thereof | 广州熵能创新材料股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-20260133203-A1 | DETECTION OF FUMARATE-DERIVED MODIFICATION IN A TEST SAMPLE | UNIV OF SOUTH CAROLINA (US) | 2026-05-14 | — | — | US | claimed |
| EP-3933019-B1 | PROCESS FOR MANUFACTURING A WATER-SOLUBLE UNIT DOSE ARTICLE | PROCTER & GAMBLE (US) | 2026-04-29 | — | — | EP | claimed |
| US-20260091014-A1 | Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2026-04-02 | — | — | US | claimed |
| EP-4709725-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Progentos Therapeutics, Inc. (US) | 2026-03-18 | — | — | EP | claimed |
| US-20260069706-A1 | METHODS FOR TREATING AUTOIMMUNE DISEASES | VOR BIOPHARMA INC (US) | 2026-03-12 | — | — | US | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260060981-A1 | COMBINATION OF 5-AMINO-2,3-DIHYDRO-1,4-PHTHALAZINEDIONE AND A FUMARIC ACID ESTER | METRIOPHARM AG (CH) | 2026-03-05 | — | — | US | claimed |
| US-12565625-B2 | Thiophosphate esters as antiwear additives for lubricants | AFTON CHEMICAL CORPORATION | 2026-03-03 | — | — | US | claimed |
| US-4780901-A | Device for the cooling of an x-ray source | THOMSON CGR (FR) | 1988-10-25 | — | — | US | claimed |
| US-4752526-A | POLYMER MODIFIED WITH UNSATURATED CARBOXYLIC ACID OR DERIVATIVE WITH WASTE PAPER, ORGANIC FIBER OR WOOD PULP | CHISSO CORPORATION (JP) | 1988-06-21 | — | — | US | claimed |
| EP-0238974-A2 | Heat resistance-improved metal-polypropylene laminate composite | Chisso Corporation (JP) | 1987-09-30 | — | — | EP | claimed |
| US-4559234-A | NITRITE-FREE PRESERVATIVES COMPRISING DINITROSYL FERROHEMOCHROME, AN ANTIOXIDANT, A SEQUESTERING AGENT, AND AN ANTIMICROBIAL AGENT | CANADIAN PATENTS AND DEVELOPMENT LIMITED (CA) | 1985-12-17 | — | — | US | claimed |
| EP-0128004-A2 | Copolymers of poly(vinyl trifluoroacetate) or poly(vinyl alcohol), process for preparing poly(vinyl alcohol) copolymers and process for preparing shaped articles from such copolymers. | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1984-12-12 | — | — | EP | claimed |
| US-4013805-A | ORGANIC AMINE OR ALKALI METAL BASE AS SOLVENT | MONSANTO COMPANY (US) | 1977-03-22 | — | — | US | claimed |
| US-3990980-A | Hybrid liquid toners | PHILIP A. HUNT CHEMICAL CORPORATION (US) | 1976-11-09 | — | — | US | claimed |
| US-3991226-A | Method of creating an image using hybrid liquid toners | PHILIP A. HUNT CHEMICAL CORPORATION (US) | 1976-11-09 | — | — | US | claimed |
| US-3971746-A | Synthetic polyisoprene rubber latex | KURARAY CO., LTD. (JA) | 1976-07-27 | — | — | US | claimed |
| US-3941912-A | Copolymer latex and paper coating composition thereof | SUMITOMO NAUGATUCK CO., LTD. (JA) | 1976-03-02 | — | — | US | claimed |