Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.61 |
| ▸ | FLT3 | P36888 | 17/20 | 0.61 |
| ▸ | CSF1R | P07333 | 6/20 | 0.61 |
| ▸ | FLT1 | P17948 | 6/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.61 |
| ▸ | RET | P07949 | 3/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.61 |
| ▸ | LTK | P29376 | 3/20 | 0.61 |
| ▸ | CDK8 | P49336 | 3/20 | 0.61 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.61 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.61 |
| ▸ | KIT | P10721 | 15/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | BLK | P51451 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6013085 | 0.89 | KDR (0.74) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL6012613 | 0.86 | KDR (0.61) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL421596 | 0.86 | KDR (0.79) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL421556 | 0.85 | KDR (0.78) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL6013316 | 0.84 | KDR (0.62) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL6013091 | 0.83 | KDR (0.62) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL6013195 | 0.81 | KDR (0.73) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL425088 | 0.80 | KDR (0.78) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL421656 | 0.79 | KDR (0.79) | KDRFLT3CSF1RFLT1PDGFRB | |
| SCHEMBL423899 | 0.79 | KDR (0.74) | KDRFLT3CSF1RFLT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | disclosed |