Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.62 |
| ▸ | KIT | P10721 | 17/20 | 0.62 |
| ▸ | FLT3 | P36888 | 16/20 | 0.62 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | FES | P07332 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6013085 | 0.92 | KDR (0.74) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL6012613 | 0.91 | KDR (0.61) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL6013091 | 0.90 | KDR (0.62) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL423059 | 0.86 | KDR (0.84) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL6013282 | 0.84 | KDR (0.61) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL6013195 | 0.83 | KDR (0.73) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL420279 | 0.81 | KDR (0.78) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL6013283 | 0.79 | KDR (0.44) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL419557 | 0.78 | KDR (0.70) | KDRKITFLT3CSF1RNTRK3 | |
| SCHEMBL419830 | 0.77 | KDR (1.00) | KDRKITFLT3CSF1RNTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | disclosed |