Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.44 |
| ▸ | FLT3 | P36888 | 12/20 | 0.44 |
| ▸ | KIT | P10721 | 10/20 | 0.44 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 4/20 | 0.33 |
| ▸ | TYK2 | P29597 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 4/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6012613 | 0.85 | KDR (0.61) | KDRFLT3KITJAK2CSF1R | |
| SCHEMBL6013085 | 0.80 | KDR (0.74) | KDRFLT3KITCSF1RPDGFRB | |
| SCHEMBL6013091 | 0.80 | KDR (0.62) | KDRFLT3KITJAK2CSF1R | |
| SCHEMBL422391 | 0.80 | KDR (0.64) | KDRFLT3KITCSF1RPDGFRB | |
| SCHEMBL6013316 | 0.79 | KDR (0.62) | KDRFLT3KITCSF1RPDGFRB | |
| SCHEMBL423454 | 0.79 | KDR (0.58) | KDRFLT3KITCSF1RPDGFRB | |
| SCHEMBL425539 | 0.76 | KIT (0.61) | KDRFLT3KITJAK2 | |
| SCHEMBL6013195 | 0.70 | KDR (0.73) | KDRFLT3KITCSF1RPDGFRB | |
| SCHEMBL423389 | 0.70 | KDR (0.62) | KDRFLT3KITCSF1RPDGFRB | |
| SCHEMBL424217 | 0.70 | KDR (0.56) | KDRFLT3KITJAK2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | disclosed |