Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517981 | 0.98 | HDAC6 (0.57) | HDAC6NAMPTCES2CES1GAA | |
| SCHEMBL5178440 | 0.98 | HDAC6 (0.57) | HDAC6NAMPTCES2CES1GAA | |
| Hydrochloric Acid SCHEMBL524680 | 0.97 | HDAC6 (0.56) | HDAC6NAMPTCES2CES1GAA | |
| Hydrochloric Acid SCHEMBL7557310 | 0.97 | HDAC6 (0.56) | HDAC6NAMPTCES2CES1GAA | |
| SCHEMBL1002785 | 0.95 | NAMPT (0.56) | HDAC6NAMPTCES2CES1GAA | |
| SCHEMBL8641718 | 0.91 | HDAC6 (0.59) | HDAC6CDK4CCND1MEN1KMT2A | |
| SCHEMBL11210960 | 0.91 | HDAC6 (0.59) | HDAC6CDK4CCND1MEN1KMT2A | |
| SCHEMBL11133367 | 0.89 | HDAC6 (0.55) | HDAC6NAMPT | |
| SCHEMBL1006489 | 0.87 | NAMPT (0.54) | HDAC6NAMPTGAAHPGDCDK4 | |
| SCHEMBL11133366 | 0.86 | TP53 (0.53) | HDAC6TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951177-A1 | IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF | Neomed Institute (CA) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014117274-A1 | IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF | NEOMED INSTITUTE (CA) | 2014-08-07 | — | — | WO | disclosed |
| US-7126027-B2 | N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives | AKZO NOBEL N.V. (NL) | 2006-10-24 | — | — | US | disclosed |