Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.68 |
| ▸ | PPARG | P37231 | 2/20 | 0.59 |
| ▸ | PPARD | Q03181 | 2/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827739 | 0.86 | ADORA3 (0.70) | ADORA3ADORA2AADORA1PPARGPPARD | |
| SCHEMBL29501856 | 0.80 | ADORA3 (0.58) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL3049180 | 0.80 | ADORA3 (0.58) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL3055654 | 0.80 | ADORA3 (0.58) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL29703267 | 0.76 | PPARG (0.76) | ADORA3ADORA2AADORA1PPARGPPARD | |
| SCHEMBL29703231 | 0.76 | PPARG (0.76) | ADORA3ADORA2AADORA1PPARGPPARD | |
| SCHEMBL29703233 | 0.76 | PPARG (0.76) | ADORA3ADORA2AADORA1PPARGPPARD | |
| SCHEMBL29501809 | 0.76 | ADORA3 (0.59) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL29703315 | 0.75 | PPARD (0.77) | ADORA3ADORA2AADORA1PPARGPPARD | |
| SCHEMBL29703255 | 0.75 | PPARD (0.77) | ADORA3ADORA2AADORA1PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252160-B1 | METHANOCARBA CYCLOALKYL NUCLEOSIDE ANALOGUES | US GOV HEALTH & HUMAN SERV (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1252160-A1 | METHANOCARBA CYCLOALKYL NUCLEOSIDE ANALOGUES | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001051490-A1 | METHANOCARBA CYCLOALKYL NUCLEOSIDE ANALOGUES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2001-07-19 | — | — | WO | disclosed |