⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455 | 0.82 | LMNA (0.41) | — | |
| Hydrochloric Acid SCHEMBL28869556 | 0.77 | TSHR (0.37) | — | |
| SCHEMBL2053410 | 0.74 | — | — | |
| Guanidine SCHEMBL28078381 | 0.74 | TSHR (0.35) | — | |
| SCHEMBL10154892 | 0.74 | — | — | |
| SCHEMBL10155578 | 0.72 | KMT2A (0.32) | — | |
| SCHEMBL12478213 | 0.72 | CA1 (0.39) | — | |
| SCHEMBL1751607 | 0.71 | — | — | |
| SCHEMBL12616464 | 0.70 | CA14 (0.37) | — | |
| SCHEMBL8781705 | 0.70 | MEN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323066-A1 | MEK INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| CN-117580835-A | MEK inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2024-02-20 | — | — | CN | disclosed |
| WO-2022221866-A1 | MEK INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-10-20 | — | — | WO | disclosed |
| US-7074743-B1 | Herbicidal composition comprising 4-iodo-2-[3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)ureidosulfonyl]benzoic esters | HOECHST SCHERING AGREVO GMBH (DE) | 2006-07-11 | — | — | US | disclosed |