Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | PDPK1 | O15530 | 7/20 | 0.74 |
| ▸ | PTGES | O14684 | 1/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.74 |
| ▸ | CA12 | O43570 | 1/20 | 0.74 |
| ▸ | PDE5A | O76074 | 1/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.74 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.74 |
| ▸ | CA1 | P00915 | 1/20 | 0.74 |
| ▸ | CA2 | P00918 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | CA3 | P07451 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6342351 | 0.91 | PTGS2 (0.90) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL8954572 | 0.88 | PTGS2 (0.79) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL7797949 | 0.88 | PTGS2 (0.79) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL15346850 | 0.88 | PTGS2 (0.78) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL15346863 | 0.87 | PTGS2 (0.77) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL3096416 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL152885 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL3246379 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| Mavacoxib SCHEMBL212699 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL18448495 | 0.86 | PTGS1 (1.00) | PTGS2PTGS1CYP2C9PDPK1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917908-B1 | A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF | COUNCIL SCIENT IND RES (IN) | 2024-08-14 | — | — | EP | claimed |
| EP-3917908-A1 | A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF | Council of Scientific & Industrial Research (IN) | 2021-12-08 | — | — | EP | claimed |
| WO-2020157771-A1 | A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2020-08-06 | — | — | WO | claimed |
| US-6492411-B1 | TREATING ARTHRITIS; REDUCED SIDE EFFECTS | G. D. SEARLE & CO. | 2002-12-10 | — | — | US | claimed |
| US-6413960-B1 | NON-STEROIDAL ANTI-INFLAMMATORY AGENTS; ACTIVE IN REDUCING PROSTAGLANDIN-INDUCED PAIN AND SWELLING; ANALGESICS; ANTIPYRETICS; ARTHRITIS; SIDE EFFECT REDUCTION | G.D. SEARLE & CO. | 2002-07-02 | — | — | US | claimed |
| US-20010055565-A1 | Method of detecting cyclooxygenase-2 | G.D. SEARLE & CO. (US) | 2001-12-27 | — | — | US | claimed |
| US-6156781-A | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation | G. D. SEARLE & CO. (US) | 2000-12-05 | — | — | US | claimed |
| US-6045773-A | Method of detecting cyclooxygenase-2 | G.D. SEARLE & CO. (US) | 2000-04-04 | — | — | US | claimed |
| EP-0859642-A2 | METHOD OF DETECTING CYCLOOXYGENASE-2 | G.D. SEARLE & CO. (US) | 1998-08-26 | — | — | EP | claimed |
| WO-1997014679-A2 | METHOD OF DETECTING CYCLOOXYGENASE-2 | G.D. SEARLE & CO. (US) | 1997-04-24 | — | — | WO | claimed |
| US-5466823-A | Antiinflammatory agents; FDA Orange book listed patent for Celebrex | G.D. SEARLE & CO. (US) | 1995-11-14 | — | — | US | claimed |
| WO-2025099444-A1 | N-Acetylserotonin (NAS) Analogues | Beckley Psytech Limited (GB) | 2025-05-15 | — | — | WO | disclosed |
| EP-3917908-B1 | A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF | COUNCIL SCIENT IND RES (IN) | 2024-08-14 | — | — | EP | disclosed |
| EP-3917908-A1 | A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF | Council of Scientific & Industrial Research (IN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020157771-A1 | A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2020-08-06 | — | — | WO | disclosed |
| US-5521207-A | Substituted pyrazolyl benzenesulfonamide for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1996-05-28 | — | — | US | disclosed |
| US-5516907-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5508426-A | ANTIARTHRITIC AGENT | G. D. SEARLE & CO. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5466823-A | Antiinflammatory agents; FDA Orange book listed patent for Celebrex | G.D. SEARLE & CO. (US) | 1995-11-14 | — | — | US | disclosed |
| WO-1995015316-A1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | G. D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010055565-A1 | Method of detecting cyclooxygenase-2 | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885PTGS1 4/4885CYP2C9 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.