SCHEMBL6014124

SCHEMBL6014124

N#Cc1ccc2oc(C#N)cc2c1

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.60
CHRM2 P08172 1/20 0.46
CHRM4 P08173 1/20 0.46
CHRM5 P08912 1/20 0.46
CHRM1 P11229 1/20 0.46
CHRM3 P20309 1/20 0.46
PGR P06401 2/20 0.44
NOS3 P29474 1/20 0.43
NOS1 P29475 1/20 0.43
NOS2 P35228 1/20 0.43
GPR35 Q9HC97 1/20 0.41
HRH3 Q9Y5N1 7/20 0.41
IMPDH2 P12268 1/20 0.40
IMPDH1 P20839 1/20 0.40
PLAU P00749 1/20 0.39
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11550694 0.84 CYP2A6 (0.60) CYP2A6PGRNOS3NOS1NOS2
SCHEMBL29082332 0.78 GPR35 (0.60) CYP2A6GPR35CA1CA2
SCHEMBL20559975 0.78 CYP2A6 (0.58) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL6014129 0.78 CYP2A6 (0.58) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL8025307 0.78 CYP2A6 (0.58) CYP2A6CA1CA2
SCHEMBL14677379 0.78 CYP2A6 (0.52) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL3999399 0.78 CYP2A6 (0.58) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL18936170 0.78 CYP2A6 (0.52) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL28128673 0.78 CYP2A6 (0.52) CYP2A6CHRM2CHRM4CHRM5CHRM1
SCHEMBL28129144 0.78 CYP2A6 (0.52) CYP2A6CHRM2CHRM4CHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1685836-A2 Antifungal activity of dicationic molecules UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2006-08-02 EP disclosed
EP-0973750-B1 SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR TREATING RETROVIRAL INFECTION UNIV NORTH CAROLINA (US) 2004-04-21 EP disclosed
US-6326395-B1 AMIDINE OR AMIDE SUBSTITUTED FURAN DERIVATIVES DUKE UNIVERSITY 2001-12-04 US disclosed
EP-1143959-A2 ANTIFUNGAL ACTIVITY OF DICATIONIC MOLECULES UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2001-10-17 EP disclosed
WO-2000015212-A2 ANTIFUNGAL ACTIVITY OF DICATIONIC MOLECULES THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2000-03-23 WO disclosed
EP-0973750-A1 SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR TREATING RETROVIRAL INFECTION The University of North Carolina at Chapel Hill (US) 2000-01-26 EP disclosed
US-5935982-A ADMINISTERING ARYLENEBIS((AMIDINO)-2-BENZIMIDAZOLE) DERIVATIVES TO TREAT HUMAN T-CELL LEUKEMIA/LYMPHOMA VIRUS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-08-10 US disclosed
WO-1998038170-A1 SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR TREATING RETROVIRAL INFECTION THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1998-09-03 WO disclosed