Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.46 |
| ▸ | KLK1 | P06870 | 2/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283833 | 0.82 | SMYD3 (0.57) | PARP1POLBSMN1; SMN2CNR1CSF1R | |
| SCHEMBL18397342 | 0.81 | PARP1 (0.52) | PARP1POLBSMN1; SMN2CNR1CSF1R | |
| SCHEMBL29859051 | 0.81 | PARP1 (0.52) | PARP1POLBSMN1; SMN2CNR1CSF1R | |
| SCHEMBL10274536 | 0.81 | KMT2A (0.50) | PARP1POLBSMN1; SMN2CNR1CSF1R | |
| SCHEMBL6014829 | 0.80 | NR3C2 (0.52) | SMN1; SMN2CSF1RKLKB1KLK1NR3C2 | |
| Hydrochloric Acid SCHEMBL29859597 | 0.78 | PARP1 (0.50) | PARP1POLBSMN1; SMN2CNR1CSF1R | |
| Hydrochloric Acid SCHEMBL18397685 | 0.78 | PARP1 (0.50) | PARP1POLBSMN1; SMN2CNR1CSF1R | |
| SCHEMBL6014106 | 0.77 | RAF1 (0.58) | CNR1MMP13BRAF | |
| SCHEMBL12259341 | 0.76 | PARP1 (0.48) | PARP1SMN1; SMN2CSF1RLOXL2L3MBTL1 | |
| SCHEMBL20118148 | 0.74 | PARP1 (0.52) | PARP1CSF1RKITBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298311-B1 | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-09 | — | — | EP | disclosed |