Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 4/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11195209 | 0.87 | MEN1 (0.72) | RAB9AMAPTEPHX1EPHX2NPC1 | |
| SCHEMBL14680572 | 0.87 | RAB9A (0.67) | RAB9AMAPTEPHX1EPHX2NPC1 | |
| SCHEMBL16942616 | 0.86 | IDH1 (0.57) | RAB9AMAPTEPHX1EPHX2NPC1 | |
| SCHEMBL14550419 | 0.85 | EPHX1 (0.58) | RAB9AEPHX1EPHX2NPC1SMN1; SMN2 | |
| SCHEMBL15975496 | 0.85 | EPHX1 (0.79) | RAB9AMAPTEPHX1EPHX2NPC1 | |
| SCHEMBL12973528 | 0.85 | EPHX1 (0.79) | RAB9AMAPTEPHX1EPHX2NPC1 | |
| SCHEMBL4118595 | 0.81 | IDH1 (0.58) | RAB9AMAPTEPHX1EPHX2NPC1 | |
| SCHEMBL13969412 | 0.81 | EPHX2 (0.53) | RAB9AEPHX1EPHX2NPC1SMN1; SMN2 | |
| SCHEMBL13945726 | 0.81 | EPHX1 (0.53) | RAB9AEPHX1EPHX2NPC1SMN1; SMN2 | |
| SCHEMBL14550519 | 0.81 | RAB9A (0.69) | RAB9AMAPTNPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298311-B1 | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-09 | — | — | EP | disclosed |