Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 6/20 | 0.54 |
| ▸ | CA1 | P00915 | 5/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13026671 | 0.86 | HTT (0.76) | HTTTDP1L3MBTL1SOS1SMN1; SMN2 | |
| SCHEMBL6851534 | 0.86 | SOS1 (0.69) | HTTSOS1CA2CA1CA12 | |
| SCHEMBL8738326 | 0.85 | HTT (0.64) | HTTTDP1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14572646 | 0.83 | HTT (0.62) | HTTTDP1L3MBTL1SOS1SMN1; SMN2 | |
| SCHEMBL8738420 | 0.81 | HTT (0.59) | HTTTDP1L3MBTL1SMN1; SMN2PGR | |
| SCHEMBL19829814 | 0.79 | HTT (0.87) | HTTTDP1L3MBTL1SOS1SMN1; SMN2 | |
| SCHEMBL83816 | 0.78 | TDP1 (0.61) | HTTTDP1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6850078 | 0.78 | CA1 (0.48) | SOS1CA2CA1CA12CA9 | |
| SCHEMBL30646273 | 0.77 | CA2 (0.73) | CA2CA1CA12CA9ALDH1A1 | |
| SCHEMBL792467 | 0.77 | CA2 (0.73) | CA2CA1CA12CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298311-B1 | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-1690853-B1 | Use of omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2010-03-10 | — | — | EP | disclosed |