Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MELK | Q14680 | 3/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015280 | 0.86 | CHEK1 (0.48) | CHEK1KDM4EMAPTKMT2AATM | |
| SCHEMBL1564680 | 0.82 | CHEK1 (0.67) | CHEK1CDK2AP1KCNH2MELKPLK4 | |
| SCHEMBL5551093 | 0.82 | SMN1; SMN2 (0.58) | KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL6015247 | 0.79 | KDM4E (0.48) | CHEK1KDM4EMAPTKMT2AATM | |
| SCHEMBL6015267 | 0.78 | KMT2A (0.47) | CHEK1KDM4EMAPTKMT2AATM | |
| SCHEMBL6015302 | 0.77 | CHEK1 (0.49) | CHEK1KDM4EMAPTKMT2AATM | |
| SCHEMBL6015254 | 0.77 | CHEK1 (0.42) | CHEK1KDM4EMAPTKMT2AATM | |
| SCHEMBL6015282 | 0.77 | KDM4E (0.46) | CHEK1KDM4EMAPTKMT2AATM | |
| SCHEMBL6015274 | 0.77 | KMT2A (0.44) | CHEK1KDM4EMAPTKMT2AATM | |
| SCHEMBL6015244 | 0.76 | KDM4E (0.44) | CHEK1KDM4EMAPTKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732920-A2 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005066163-A2 | THIOPHENE DERIVATIVES AS CHK 1 INIHIBITORS | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |