Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554766 | 0.84 | MEN1 (0.58) | KMT2AMEN1NPC1MAPTCDK5 | |
| SCHEMBL1563750 | 0.83 | CHEK1 (0.52) | CHEK1SYKPTK2 | |
| SCHEMBL6015254 | 0.78 | CHEK1 (0.42) | KMT2AMAPTCHEK1KDM4EATM | |
| SCHEMBL6015246 | 0.77 | CHEK1 (0.48) | KMT2AMAPTCHEK1KDM4EATM | |
| SCHEMBL6015247 | 0.76 | KDM4E (0.48) | KMT2AMAPTLMNACHEK1KDM4E | |
| SCHEMBL6015267 | 0.75 | KMT2A (0.47) | KMT2AMAPTLMNACHEK1KDM4E | |
| SCHEMBL6015282 | 0.75 | KDM4E (0.46) | KMT2AMAPTLMNACHEK1KDM4E | |
| SCHEMBL13534617 | 0.74 | MEN1 (0.55) | KMT2AMEN1NPC1MAPTCDK5 | |
| SCHEMBL2446469 | 0.72 | ALOX15 (0.59) | NPC1ALOX15 | |
| SCHEMBL4476146 | 0.71 | CCNA2 (0.69) | KMT2AMEN1NPC1MAPTCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732920-A2 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005066163-A2 | THIOPHENE DERIVATIVES AS CHK 1 INIHIBITORS | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |