Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31129989 | 1.00 | CYP2A6 (0.53) | CYP2A6ALDH1A1KDM4EMAPTPLG | |
| SCHEMBL29956133 | 0.88 | MAPT (0.60) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL14832262 | 0.88 | MAPT (0.60) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL31129913 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL29935657 | 0.73 | PIM3 (0.65) | CYP2A6ALDH1A1KDM4EMAPTPLG | |
| SCHEMBL1049957 | 0.73 | PIM3 (0.65) | CYP2A6ALDH1A1KDM4EMAPTPLG | |
| SCHEMBL15902102 | 0.71 | ALDH1A1 (0.58) | CYP2A6ALDH1A1KDM4EMAPTPLG | |
| SCHEMBL31130039 | 0.71 | MAPT (0.54) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL9377060 | 0.71 | CYP2A6 (0.66) | CYP2A6ALDH1A1KDM4EMAPTPLG | |
| SCHEMBL29956305 | 0.71 | CYP2A6 (0.66) | CYP2A6ALDH1A1KDM4EMAPTPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | disclosed |