Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016076 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2HRH3BACE1TDP1TSHR | |
| SCHEMBL6015958 | 0.89 | TSHR (0.42) | SMN1; SMN2TSHRKDM4EPOLB | |
| SCHEMBL6015878 | 0.80 | TSHR (0.51) | SMN1; SMN2HRH3TDP1TSHRKDM4E | |
| SCHEMBL6015938 | 0.80 | TSHR (0.51) | SMN1; SMN2HRH3TDP1TSHRKDM4E | |
| SCHEMBL6015789 | 0.80 | — | — | |
| SCHEMBL6015751 | 0.79 | — | — | |
| SCHEMBL7624616 | 0.77 | PIM1 (0.35) | HRH3 | |
| SCHEMBL6015772 | 0.77 | HPGD (0.51) | SMN1; SMN2TSHRKDM4ECYP1A2CYP2D6 | |
| SCHEMBL6016003 | 0.76 | TLR7 (0.36) | SMN1; SMN2TDP1TSHRKDM4ECYP1A2 | |
| SCHEMBL8704734 | 0.70 | HRH3 (0.55) | SMN1; SMN2HRH3BACE1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |