Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | BCL6 | P41182 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016169 | 0.92 | SYK (0.45) | SYKGRM4CCNT1CCNE1CDK2 | |
| SCHEMBL6016679 | 0.83 | SMN1; SMN2 (0.40) | SYKGRM4SMN1; SMN2MEN1MAPT | |
| SCHEMBL6016391 | 0.83 | SYK (0.59) | SYK | |
| SCHEMBL6016334 | 0.83 | SYK (0.59) | SYK | |
| SCHEMBL6016477 | 0.82 | SYK (0.59) | SYKCCNT1CCNE1CDK2CDK9 | |
| SCHEMBL6016153 | 0.82 | SYK (0.59) | SYKCCNT1CCNE1CDK2CDK9 | |
| SCHEMBL6016285 | 0.81 | SYK (0.59) | SYKEGFR | |
| SCHEMBL6016415 | 0.81 | SYK (0.59) | SYKEGFR | |
| SCHEMBL6016171 | 0.79 | GRM4 (0.50) | SYKGRM4 | |
| SCHEMBL6016125 | 0.76 | SYK (0.59) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |