Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 11/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655986 | 0.82 | AURKA (0.55) | ALKAURKAAURKBMAPK8CDK2 | |
| SCHEMBL655647 | 0.79 | AURKA (0.57) | ALKAURKAAURKBMAPK8CDK2 | |
| SCHEMBL6016210 | 0.78 | GLO1 (0.54) | ALKGLO1AURKAAURKBMAPK8 | |
| SCHEMBL656107 | 0.74 | GLO1 (0.78) | ALKGLO1AURKAAURKBMAPK8 | |
| SCHEMBL654192 | 0.72 | AURKA (0.59) | ALKGLO1AURKAAURKBMAPK8 | |
| SCHEMBL657530 | 0.72 | AURKA (0.82) | ALKAURKAAURKBMAPK8CDK2 | |
| SCHEMBL1707645 | 0.71 | GLO1 (0.73) | ALKGLO1AURKAAURKBMAPK8 | |
| SCHEMBL657529 | 0.71 | SYK (0.75) | AURKAAURKBMAPK8CDK2GSK3A | |
| SCHEMBL6016208 | 0.71 | CDK2 (0.64) | GLO1AURKAAURKBMAPK8CDK2 | |
| Hydrochloric Acid SCHEMBL1707850 | 0.71 | GLO1 (0.72) | ALKGLO1AURKAAURKBMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |