Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.71 |
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | ITK | Q08881 | 3/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | CTSC | P53634 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016685 | 0.86 | SYK (0.63) | SYKEGFRITKBTKCTSC | |
| SCHEMBL6016323 | 0.85 | SYK (0.58) | SYKEGFRITKAURKA | |
| SCHEMBL656652 | 0.84 | SYK (1.00) | SYKEGFRITKBTKCTSC | |
| SCHEMBL6016437 | 0.84 | SYK (0.59) | SYKAURKA | |
| SCHEMBL6016596 | 0.84 | SYK (0.68) | SYKAURKA | |
| SCHEMBL4935260 | 0.84 | SYK (0.68) | SYKAURKA | |
| SCHEMBL657388 | 0.83 | SYK (0.77) | SYKEGFRITKBTKCTSC | |
| SCHEMBL6016309 | 0.83 | SYK (0.56) | SYKEGFRITKBTK | |
| SCHEMBL6016199 | 0.82 | SYK (0.52) | SYKITKBTKAURKA | |
| SCHEMBL6017059 | 0.82 | SYK (0.66) | SYKEGFRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |