Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.58 |
| ▸ | BCL6 | P41182 | 9/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016759 | 0.87 | SYK (0.49) | SYKBCL6NCOR2AURKACDK1 | |
| SCHEMBL3089169 | 0.86 | SYK (0.55) | SYKBCL6NCOR2EGFRITK | |
| SCHEMBL6016271 | 0.85 | SYK (0.71) | SYKEGFRITKAURKA | |
| SCHEMBL3857488 | 0.84 | SYK (0.53) | SYKEGFRITKAURKACDK1 | |
| SCHEMBL656273 | 0.83 | SYK (0.59) | SYKBCL6NCOR2AURKA | |
| SCHEMBL6016266 | 0.83 | SYK (0.56) | SYKBCL6NCOR2EGFRITK | |
| SCHEMBL6016485 | 0.83 | SYK (0.65) | SYKBCL6 | |
| SCHEMBL6016263 | 0.82 | SYK (0.48) | SYKAURKACDK1 | |
| SCHEMBL6016199 | 0.82 | SYK (0.52) | SYKITKAURKACDK1 | |
| SCHEMBL656523 | 0.81 | SYK (0.61) | SYKBCL6NCOR2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |