Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 13/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 13/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.45 |
| ▸ | CASP1 | P29466 | 11/20 | 0.45 |
| ▸ | CASP7 | P55210 | 11/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.45 |
| ▸ | USP2 | O75604 | 10/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.45 |
| ▸ | TP53 | P04637 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 9/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpiperazine SCHEMBL6016376 | 0.92 | TSHR (0.46) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| SCHEMBL4120279 | 0.86 | ALDH1A1 (0.45) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| SCHEMBL4124274 | 0.86 | ALDH1A1 (0.43) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| SCHEMBL4123893 | 0.86 | TACR1 (0.47) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| SCHEMBL4129695 | 0.86 | TSHR (0.51) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| SCHEMBL2948308 | 0.86 | PTPN11 (0.52) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| Piperazine SCHEMBL6016563 | 0.85 | TACR1 (0.47) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| SCHEMBL4125241 | 0.85 | ALDH1A1 (0.45) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| Piperazine SCHEMBL6016442 | 0.85 | ALDH1A1 (0.44) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 | |
| Piperazine SCHEMBL6016624 | 0.84 | ALDH1A1 (0.44) | ALDH1A1CYP1A2HSD17B10CYP3A4CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-B1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | disclosed |
| EP-1187815-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| US-6274588-B1 | NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| WO-2000073279-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |