Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.65 |
| ▸ | BCL6 | P41182 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016266 | 0.90 | SYK (0.56) | SYKBCL6 | |
| SCHEMBL6017059 | 0.87 | SYK (0.66) | SYK | |
| SCHEMBL3089169 | 0.87 | SYK (0.55) | SYKBCL6 | |
| SCHEMBL6016323 | 0.83 | SYK (0.58) | SYKBCL6 | |
| SCHEMBL6016710 | 0.82 | SYK (0.62) | SYK | |
| SCHEMBL6016711 | 0.82 | SYK (0.62) | SYK | |
| SCHEMBL11987138 | 0.79 | SYK (1.00) | SYK | |
| SCHEMBL658551 | 0.78 | SYK (0.69) | SYKBCL6 | |
| SCHEMBL659529 | 0.77 | SYK (0.65) | SYKBCL6PTK2 | |
| SCHEMBL6016309 | 0.77 | SYK (0.56) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |