Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 14/20 | 0.72 |
| ▸ | CDK1 | P06493 | 7/20 | 0.72 |
| ▸ | CDK2 | P24941 | 13/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.68 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.68 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.68 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.66 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.66 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.66 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | PAK4 | O96013 | 1/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | INSR | P06213 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016491 | 1.00 | CDK5 (0.72) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL6016653 | 1.00 | CDK5 (0.72) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL6016657 | 1.00 | CDK5 (0.72) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL6016726 | 1.00 | CDK5 (0.72) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL6016536 | 0.86 | CDK1 (0.72) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL6016531 | 0.86 | CDK1 (0.72) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL6016588 | 0.85 | CDK1 (0.71) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL6016542 | 0.85 | CDK1 (0.71) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL6016540 | 0.85 | CDK1 (0.71) | CDK5CDK1CDK2CCNA2CCNA1 | |
| SCHEMBL1218376 | 0.84 | CDK1 (1.00) | CDK5CDK1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244668-B1 | PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF | UNIVERSITAIRE INSTELLING ANTWE (BE) | 2006-04-05 | — | — | EP | claimed |
| US-20030187261-A1 | Purine derivatives, process for their preparation and use thereof | USTAV EXPERIMANTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY (CZ) | 2003-10-02 | — | — | US | claimed |
| EP-1244668-A1 | PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF | UNIVERSITAIRE INSTELLING ANTWERPEN (BE) | 2002-10-02 | — | — | EP | claimed |
| WO-2001049688-A1 | PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF | UNIVERSITAIRE INSTELLING ANTWERPEN (BE) | 2001-07-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187261-A1 | Purine derivatives, process for their preparation and use thereof | DCK, DTYMK, CCNK | CDK5 23/4885CDK1 7/4885CDK2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.