Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.66 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | MERTK | Q12866 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654156 | 0.80 | SYK (1.00) | SYKBTKAURKA | |
| SCHEMBL2519190 | 0.77 | PKMYT1 (0.71) | SYKAURKA | |
| R-112 SCHEMBL655935 | 0.77 | SYK (1.00) | SYKMAPK8AURKAAURKBCDK19 | |
| SCHEMBL656905 | 0.77 | SYK (1.00) | SYKMAPK8 | |
| R-112 SCHEMBL29360016 | 0.77 | SYK (1.00) | SYKMAPK8AURKAAURKBCDK19 | |
| R-112 SCHEMBL31294216 | 0.77 | SYK (1.00) | SYKMAPK8AURKAAURKBCDK19 | |
| SCHEMBL15586127 | 0.75 | BTK (0.66) | BTK | |
| SCHEMBL656990 | 0.75 | SYK (1.00) | SYKAURKA | |
| SCHEMBL1040138 | 0.74 | GLO1 (0.69) | SYKMAPK8AURKAAURKBCDK19 | |
| SCHEMBL655564 | 0.74 | SYK (1.00) | SYKBTKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |