Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 17/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.40 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016358 | 0.92 | ITGB3 (0.50) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL6016500 | 0.87 | ITGAV (0.51) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL6016495 | 0.86 | ITGAV (0.40) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL2954954 | 0.85 | ITGAV (0.51) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL2954956 | 0.85 | ITGAV (0.51) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL2946838 | 0.85 | ITGAV (0.46) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL13709241 | 0.85 | ITGAV (0.46) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL275041 | 0.85 | ITGAV (0.46) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL2949030 | 0.85 | ITGAV (0.46) | ITGAVITGB3ITGB6ITGB5ITGB1 | |
| SCHEMBL2957399 | 0.85 | ITGAV (0.46) | ITGAVITGB3ITGB6ITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210348-B9 | NAPHTHYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1210348-B1 | NAPHTHYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2005-09-28 | — | — | EP | disclosed |
| US-6743800-B1 | VITRONECTIN RECEPTOR ANTAGONISTS AND INHIBITORS OF CELL ADHESION; OSTEOPOROSIS, ANGIOGENESIS INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-06-01 | — | — | US | disclosed |
| EP-1210348-A1 | NAPHTHYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001002398-A1 | NAPHTHYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-11 | — | — | WO | disclosed |
| EP-1065207-A1 | Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them | Aventis Pharma Deutschland GmbH (DE) | 2001-01-03 | — | — | EP | disclosed |