Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.45 |
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016654 | 0.95 | SYK (0.64) | SYKEGFRCDK1CHEK1FLT3 | |
| SCHEMBL6016192 | 0.93 | SYK (0.62) | SYKEGFRCDK1KDRCHEK1 | |
| SCHEMBL6016559 | 0.88 | SYK (0.64) | SYKEGFRCHEK1FLT3STK17A | |
| SCHEMBL6016257 | 0.84 | SYK (0.59) | SYKEGFR | |
| SCHEMBL6016702 | 0.84 | SYK (0.59) | SYKEGFR | |
| SCHEMBL6016351 | 0.84 | SYK (0.64) | SYKEGFR | |
| SCHEMBL6016543 | 0.84 | SYK (0.55) | SYKEGFRSTK17A | |
| SCHEMBL6016150 | 0.83 | SYK (0.62) | SYK | |
| SCHEMBL6016729 | 0.81 | SYK (0.60) | SYK | |
| SCHEMBL6016718 | 0.79 | SYK (0.69) | SYKEGFRSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |