Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016852 | 1.00 | EPHX1 (0.37) | EPHX1NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL6488112 | 0.83 | EPHX1 (0.35) | EPHX1NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL6016799 | 0.82 | MEN1 (0.39) | EPHX1NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL6016798 | 0.82 | MEN1 (0.39) | EPHX1NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL7564909 | 0.75 | EPHX1 (0.36) | EPHX1NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL501214 | 0.74 | NR1H2 (0.35) | EPHX1NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL20031478 | 0.71 | NR1H2 (0.60) | EPHX1NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL29180653 | 0.71 | NR1H2 (0.60) | EPHX1NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL29057889 | 0.70 | HSD17B10 (0.41) | EPHX1CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL28959377 | 0.70 | NR1H2 (0.38) | EPHX1NR1H2CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615886-A1 | [C]-FUSED BICYCLIC PROLINE DERIVATIVES AND THEIR USE FOR TREATING ARTHRITIC CONDITIONS | Warner-Lambert Company LLC (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092134-A1 | [C]-FUSED BICYCLIC PROLINE DERIVATIVES AND THEIR USE FOR TREATING ARTHRITIC CONDITIONS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-28 | — | — | WO | disclosed |