Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL500778 | 0.80 | ELANE (0.38) | KMT2ACTSK | |
| SCHEMBL6488112 | 0.77 | EPHX1 (0.35) | NR1H2GPR119MEN1ALDH1A1MAPT | |
| SCHEMBL6016852 | 0.74 | EPHX1 (0.37) | NR1H2GPR119MEN1ALDH1A1MAPT | |
| SCHEMBL6016853 | 0.74 | EPHX1 (0.37) | NR1H2GPR119MEN1ALDH1A1MAPT | |
| SCHEMBL4767709 | 0.73 | CHRM2 (0.38) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL143165 | 0.73 | CHRM2 (0.38) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL144061 | 0.73 | CHRM2 (0.38) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6016798 | 0.71 | MEN1 (0.39) | NR1H2GPR119MEN1ALDH1A1MAPT | |
| SCHEMBL6016799 | 0.71 | MEN1 (0.39) | NR1H2GPR119MEN1ALDH1A1MAPT | |
| SCHEMBL31667788 | 0.71 | NR1H2 (0.37) | NR1H2GPR119HPGDCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106059-B2 | Substituted pyrazines that inhibit protease cathepsin S and HCV replication | VIROBAY, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| EP-2215076-A2 | COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION | Virobay, Inc. (US) | 2010-08-11 | — | — | EP | disclosed |
| US-20090270415-A1 | COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION | VIROBAY, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| WO-2009055467-A2 | COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION | VIROBAY, INC. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270415-A1 | COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION | CTSS, CTSV, CTSE | NR1H2 2057/4885GPR119 2439/4885MEN1 3350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.