Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | BRAF | P15056 | 5/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.41 |
| ▸ | CBLB | Q13191 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3594026 | 0.86 | CBLB (0.53) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL6017011 | 0.79 | FAAH (0.51) | KDRBRAFRAF1KDM1ARCOR1 | |
| SCHEMBL3591965 | 0.79 | RAF1 (0.47) | KDRBRAFRAF1KDM1ARCOR1 | |
| SCHEMBL3593297 | 0.79 | BRAF (0.48) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL3589751 | 0.77 | KDR (0.53) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL3602119 | 0.75 | KDR (0.49) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL3596282 | 0.74 | RET (0.62) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL3603688 | 0.74 | KDR (0.49) | KDRBRAFRAF1KDM1ARCOR1 | |
| SCHEMBL3604416 | 0.70 | GRM5 (0.48) | RAF1 | |
| SCHEMBL4246148 | 0.69 | CHEK2 (0.53) | KDRBRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643991-A1 | BENZIMIDAZOLE CARBOXAMIDES AS RAF KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005004863-A1 | BENZIMIDAZOLE CARBOXAMIDES AS RAF KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | WO | disclosed |