Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.49 |
| ▸ | EHMT1 | Q9H9B1 | 6/20 | 0.49 |
| ▸ | BCL6 | P41182 | 2/20 | 0.47 |
| ▸ | IDH2 | P48735 | 1/20 | 0.46 |
| ▸ | GALR1 | P47211 | 4/20 | 0.44 |
| ▸ | GALR2 | O43603 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4829436 | 0.99 | EHMT2 (0.50) | EHMT2EHMT1BCL6IDH2GALR1 | |
| Hydrochloric Acid SCHEMBL5550552 | 0.98 | EHMT2 (0.49) | EHMT2EHMT1BCL6IDH2GALR1 | |
| Hydrochloric Acid SCHEMBL5550550 | 0.97 | EHMT2 (0.49) | EHMT2EHMT1BCL6IDH2GALR1 | |
| Hydrochloric Acid SCHEMBL5432850 | 0.97 | EHMT2 (0.48) | EHMT2EHMT1BCL6IDH2GALR1 | |
| SCHEMBL6856715 | 0.96 | EHMT2 (0.54) | EHMT2EHMT1BCL6IDH2GALR1 | |
| SCHEMBL4839206 | 0.95 | BCL6 (0.50) | EHMT2EHMT1BCL6IDH2GALR1 | |
| Malonic Acid SCHEMBL4829481 | 0.93 | EHMT2 (0.45) | EHMT2EHMT1BCL6IDH2GALR1 | |
| Fumaric Acid SCHEMBL4836755 | 0.92 | EHMT2 (0.44) | EHMT2EHMT1BCL6IDH2GALR1 | |
| Maleic Acid SCHEMBL4835112 | 0.92 | EHMT2 (0.44) | EHMT2EHMT1BCL6IDH2GALR1 | |
| Succinic Acid SCHEMBL4835600 | 0.92 | EHMT2 (0.44) | EHMT2EHMT1BCL6IDH2GALR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132423-B2 | Methods and compositions of novel triazine compounds | REDDY US THERAPEUTICS, INC. (US) | 2006-11-07 | — | — | US | disclosed |