Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5561271 | 0.99 | CNR2 (0.46) | CNR2NPSR1HTTATMTDP1 | |
| Bromide SCHEMBL5560141 | 0.88 | MAPT (0.41) | CNR2NPSR1HTTGAAALDH1A1 | |
| Bromide SCHEMBL5565800 | 0.87 | HTT (0.48) | NPSR1HTTALDH1A1LMNAMAPT | |
| Bromide SCHEMBL5560418 | 0.87 | HTT (0.43) | NPSR1HTTALDH1A1LMNAMAPT | |
| Bromide SCHEMBL5564610 | 0.85 | ABL1 (0.43) | CNR2NPSR1HTTGAAALDH1A1 | |
| Bromide SCHEMBL5559706 | 0.84 | MAPT (0.46) | CNR2NPSR1HTTTDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL5565412 | 0.84 | ALDH1A1 (0.47) | NPSR1HTTATML3MBTL1GAA | |
| Bromide SCHEMBL5565101 | 0.84 | HTT (0.43) | NPSR1HTTL3MBTL1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL5559797 | 0.82 | MAPT (0.41) | NPSR1HTTTDP1L3MBTL1GAA | |
| Hydrochloric Acid SCHEMBL5564730 | 0.82 | ALDH1A1 (0.45) | NPSR1HTTTDP1GAASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653969-A4 | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | JAPAN TOBACCO INC (JP) | 2006-12-20 | — | — | EP | disclosed |
| EP-1653969-A2 | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | Japan Tabacco Inc. (JP) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005013907-A2 | PYRROLO[1,2-B]PYRIDAZINE DERIVATIVES | JAPAN TOBACCO INC. (JP) | 2005-02-17 | — | — | WO | disclosed |