Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567889 | 1.00 | EGFR (0.63) | EGFRERBB2LCKKCNH2 | |
| SCHEMBL5564723 | 0.93 | EGFR (0.63) | EGFRERBB2LCKKCNH2 | |
| SCHEMBL6017179 | 0.92 | EGFR (0.62) | EGFRERBB2LCKKCNH2 | |
| SCHEMBL5564331 | 0.92 | EGFR (0.62) | EGFRERBB2LCKKCNH2 | |
| SCHEMBL5566166 | 0.89 | EGFR (0.67) | EGFRERBB2LCKKCNH2 | |
| SCHEMBL5569400 | 0.86 | EGFR (0.65) | EGFRERBB2LCK | |
| SCHEMBL6017522 | 0.86 | EGFR (0.65) | EGFRERBB2LCK | |
| SCHEMBL5564685 | 0.85 | EGFR (0.67) | EGFRERBB2LCKKCNH2 | |
| SCHEMBL5564542 | 0.85 | EGFR (0.58) | EGFRERBB2LCKKCNH2 | |
| SCHEMBL5567987 | 0.85 | EGFR (0.63) | EGFRERBB2LCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664028-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026151-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |