Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569400 | 1.00 | EGFR (0.65) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL5569118 | 0.92 | ERBB2 (0.76) | EGFRERBB2LCKAURKARPS6KB1 | |
| SCHEMBL4384983 | 0.87 | ERBB2 (0.85) | EGFRERBB2 | |
| SCHEMBL5697194 | 0.87 | ERBB2 (0.85) | EGFRERBB2 | |
| SCHEMBL4387008 | 0.87 | ERBB2 (0.85) | EGFRERBB2 | |
| SCHEMBL5564723 | 0.86 | EGFR (0.63) | EGFRERBB2LCK | |
| SCHEMBL6017201 | 0.86 | EGFR (0.63) | EGFRERBB2LCK | |
| SCHEMBL5567889 | 0.86 | EGFR (0.63) | EGFRERBB2LCK | |
| SCHEMBL4384872 | 0.85 | ERBB2 (0.81) | EGFRERBB2 | |
| SCHEMBL5696763 | 0.85 | ERBB2 (0.81) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664028-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026151-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |