Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 9/20 | 0.66 |
| ▸ | SYK | P43405 | 8/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | CDK1 | P06493 | 2/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.61 |
| ▸ | GSK3A | P49840 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 2/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | FES | P07332 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016208 | 0.96 | CDK2 (0.64) | CDK2CCNA2AURKASYKAURKB | |
| SCHEMBL656106 | 0.86 | GLO1 (0.67) | CDK2AURKASYKAURKBCDK1 | |
| SCHEMBL340035 | 0.85 | JAK3 (0.57) | CDK2CCNA2AURKASYKAURKB | |
| SCHEMBL341846 | 0.81 | JAK1 (0.60) | CDK2CCNA2AURKASYKCDK1 | |
| SCHEMBL656464 | 0.80 | AURKA (0.86) | CDK2AURKASYKAURKBCDK1 | |
| SCHEMBL656765 | 0.80 | AURKA (1.00) | CDK2AURKASYKAURKBCDK1 | |
| Hydrochloric Acid SCHEMBL3295506 | 0.79 | AURKA (0.53) | CDK2CCNA2AURKASYKAURKB | |
| SCHEMBL13300708 | 0.79 | AURKA (0.56) | CDK2CCNA2AURKASYKAURKB | |
| SCHEMBL657089 | 0.79 | SYK (1.00) | CDK2AURKASYKAURKBCDK1 | |
| SCHEMBL4937858 | 0.77 | SYK (0.97) | CDK2AURKASYKAURKBCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |