Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.50 |
| ▸ | EGFR | P00533 | 6/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754733 | 1.00 | ENPP1 (0.52) | ENPP1PDE10AEGFRKDRFLT1 | |
| SCHEMBL4375009 | 0.87 | EGFR (0.63) | ENPP1PDE10AEGFRKDRFLT1 | |
| SCHEMBL3427416 | 0.84 | KDR (0.62) | ENPP1PDE10AEGFRKDRFLT1 | |
| SCHEMBL14489836 | 0.83 | EGFR (0.52) | ENPP1PDE10AEGFRKDRFLT1 | |
| SCHEMBL29465791 | 0.82 | PIK3CD (0.54) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL665187 | 0.82 | PIK3CD (0.54) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL29465790 | 0.82 | PIK3CD (0.54) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL2453138 | 0.82 | PIK3CD (0.54) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL14489848 | 0.82 | ACHE (0.57) | EGFREPHB4ERBB2 | |
| SCHEMBL3129523 | 0.82 | EGFR (0.56) | ENPP1EGFREPHB4ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664028-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026151-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |