Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345537 | 0.85 | MIF (0.43) | KMT2AMEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL22758084 | 0.75 | MEN1 (0.41) | KMT2AMEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL18704255 | 0.74 | KMT2A (0.52) | KMT2AMEN1SMN1; SMN2POLBMIF | |
| SCHEMBL2799510 | 0.71 | KMT2A (0.63) | KMT2AMEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL2797975 | 0.71 | KMT2A (0.40) | KMT2AMEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL19433308 | 0.70 | MEN1 (0.42) | KMT2AMEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL10887061 | 0.70 | KMT2A (0.50) | KMT2AMEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL363513 | 0.70 | KMT2A (0.56) | KMT2AMEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL17080108 | 0.69 | CYP2C19 (0.44) | KMT2AMEN1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL13865442 | 0.69 | MIF (0.45) | KMT2AMEN1NPC1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684694-A2 | AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051304-A2 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |