Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.51 |
| ▸ | RARG | P13631 | 11/20 | 0.51 |
| ▸ | RARA | P10276 | 9/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 6/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017460 | 1.00 | RARB (0.51) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL4418790 | 0.84 | RARB (0.63) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL4418785 | 0.84 | RARB (0.63) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL8522220 | 0.81 | RARB (0.58) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL8522221 | 0.81 | RARB (0.58) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL6017459 | 0.79 | CYP26A1 (0.51) | RARBRARGRARACYP26A1SNCA | |
| SCHEMBL4315172 | 0.77 | RARB (0.75) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL4315169 | 0.77 | RARB (0.75) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL9822716 | 0.74 | CYP26A1 (0.48) | RARBRARGRARACYP26A1PTGS2 | |
| SCHEMBL9822702 | 0.74 | CYP26A1 (0.48) | RARBRARGRARACYP26A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704139-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RAR y RETINOID RECEPTORS | Allergan, Inc. (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005066116-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RARϜ RETINOID RECEPTORS | ALLERGAN, INC. (US) | 2005-07-21 | — | — | WO | disclosed |