Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.46 |
| ▸ | F3 | P13726 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.45 |
| ▸ | SNCA | P37840 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 2/20 | 0.42 |
| ▸ | P4HB | P07237 | 1/20 | 0.42 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418790 | 0.86 | RARB (0.63) | CYP26A1MAPTLMNANPSR1NPC1 | |
| SCHEMBL4418785 | 0.86 | RARB (0.63) | CYP26A1MAPTLMNANPSR1NPC1 | |
| SCHEMBL9187417 | 0.82 | CYP26A1 (0.60) | CYP26A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL9187421 | 0.82 | CYP26A1 (0.60) | CYP26A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL9822702 | 0.80 | CYP26A1 (0.48) | CYP26A1MAPTLMNARARARARB | |
| SCHEMBL9822716 | 0.80 | CYP26A1 (0.48) | CYP26A1MAPTLMNARARARARB | |
| SCHEMBL6017458 | 0.79 | RARB (0.51) | CYP26A1LMNANPSR1NPC1RARA | |
| SCHEMBL6017460 | 0.79 | RARB (0.51) | CYP26A1LMNANPSR1NPC1RARA | |
| SCHEMBL4315172 | 0.78 | RARB (0.75) | CYP26A1LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL17302425 | 0.78 | CYP26A1 (0.64) | CYP26A1MAPTLMNANPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704139-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RAR y RETINOID RECEPTORS | Allergan, Inc. (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005066116-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RARϜ RETINOID RECEPTORS | ALLERGAN, INC. (US) | 2005-07-21 | — | — | WO | disclosed |