Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568052 | 0.92 | EGFR (0.63) | EGFRERBB2FAAHERBB4 | |
| SCHEMBL5568894 | 0.85 | EGFR (0.64) | EGFRERBB2ERBB4 | |
| SCHEMBL5564412 | 0.85 | EGFR (0.76) | EGFRERBB2ERBB4 | |
| SCHEMBL5564631 | 0.83 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL5567844 | 0.79 | ERBB2 (0.58) | EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL5564704 | 0.78 | ERBB2 (0.57) | EGFRERBB2 | |
| SCHEMBL5564452 | 0.78 | EGFR (0.61) | EGFRERBB2ERBB4 | |
| SCHEMBL5565179 | 0.78 | EGFR (0.56) | EGFRERBB2ERBB4 | |
| SCHEMBL6017397 | 0.76 | EGFR (0.60) | EGFRERBB2ERBB4 | |
| SCHEMBL3434522 | 0.76 | EGFR (1.00) | EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664028-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | claimed |
| WO-2005026151-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | claimed |