Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.34 |
| ▸ | KIF11 | P52732 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427700 | 0.85 | NR3C1 (0.45) | NR3C1AKR1B1KIF11MAPTAKR1B10 | |
| SCHEMBL3428145 | 0.82 | NR3C1 (0.61) | NR3C1AKR1B1KIF11 | |
| SCHEMBL3428327 | 0.69 | AKR1B1 (0.46) | AKR1B1KIF11MAPTAKR1B10AKR1A1 | |
| SCHEMBL3427586 | 0.67 | NR3C1 (0.73) | NR3C1 | |
| SCHEMBL13761822 | 0.67 | AKR1B1 (0.47) | AKR1B1KIF11MAPTAKR1B10AKR1A1 | |
| SCHEMBL13160400 | 0.67 | NR3C1 (0.45) | NR3C1ALDH1A1LMNAAAK1 | |
| SCHEMBL13160268 | 0.66 | NR3C1 (0.55) | NR3C1 | |
| SCHEMBL3426166 | 0.65 | NR3C1 (0.72) | NR3C1 | |
| SCHEMBL3426301 | 0.64 | NR3C1 (0.33) | NR3C1 | |
| SCHEMBL3424758 | 0.64 | NR3C1 (0.42) | NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727813-A1 | 2-PROPANOL AND 2-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-12-06 | — | — | EP | claimed |
| WO-2005090336-A1 | 2-PROPANOL AND 2-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-09-29 | — | — | WO | claimed |